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TWO BOTTLES Life Extension Pro Resolving Mediators

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Life Extension

About this item

This formula uses SPM precursors from marine oil to promote the natural clearing of cellular debris, help maintain a healthy balance of cytokine compounds, and support healthy tissue rejuvenation.



Specialized pro-resolving mediators (SPMs) help maintain the body’s healthy post-inflammatory response to support whole-body health. These powerful compounds promote the natural clearing of cellular debris, help maintain a healthy balance of cytokine compounds, and support healthy tissue rejuvenation.

Encouraging your body’s post-inflammatory response goes a long way toward maintaining whole-body health.

Pro-Resolving Mediators Benefits

  • Helps maintain the body’s healthy post-inflammatory response
  • Supports the body’s natural process for clearing cellular debris
  • Helps maintain healthy cytokine balance & supports healthy tissue rejuvenation
  • Contains highly purified SPM precursors derived from marine oil
  • Works best when taken in conjunction with formulas like Curcumin Elite™

An Incredible Nutrient Derived From Marine Oil

The body creates specialized pro-resolving mediators from fatty acids such as EPA and DHA omega-3s. But fish oil is not completely converted to SPMs, so you may not get the optimal health benefit from taking a fish oil alone. In fact, research indicates that SPMs and SPM precursors (such as 17-HDHA and 18-HEPE in this formula) are actually better for promoting a healthy post-inflammatory response.

Product Details

A healthy dietary regimen should include nutrients that promote a healthy inflammatory response, as well as those that help maintain a healthy post-inflammatory response. Pro-Resolving Mediators do just that: promote a healthy post-inflammatory response, which in turn supports whole-body health.

Derived from Marine Oil

Resolvins and maresins are the two principle types of specialized pro-resolving mediators, or SPMs. They’re created by the body from fatty acids such as EPA and DHA omega-3s.

Why not just take a fish oil supplement? Because fish oil is not completely converted to SPMs, and may not obtain sufficient SPM levels. Fish oil and SPMs also perform distinct activities in the body and are not interchangeable. Research indicates that ingesting SPMs and precursors like 17-HDHA and 18-HEPE is better than taking fish oil when a healthy post-inflammatory response is required, in order to promote whole-body health.


The body’s natural biological response to inflammation can cause cellular debris. This debris can affect the function of otherwise-healthy cells. SPMs encourage the body’s existing pathways for naturally identifying and removing cellular debris, as well as recycling cells that no longer function optimally.


The body naturally maintains a balance between chemical compounds called cytokines. With normal aging, this natural balance declines. SPMs help maintain a healthy balance of cytokines in the body.


It is important to support the natural biological process for rejuvenating youthful, healthy system-wide functionality. SPMs do just that by promoting the body’s natural processes for revitalizing healthy skin, organs and other vital tissues.

Part of a Healthy Whole-Body Regimen

Pro-resolving mediators helps maintain the body’s healthy post-inflammatory response. We recommend taking SPMs along with Curcumin Elite™ Turmeric Extract as part of a comprehensive health regimen.


Not for sale outside the USA.

Supplement Facts

Serving Size 1 softgels

Amount Per Serving



Total Fat

0.5 g


<5 mg

Marine Lipid Concentrate

500 mg

[providing 300 mcg of Pro-Resolving Mediators including 18-hydroxyeicosapentaenoic acid (18-HEPE), 17-hydroxydocosahexaenoic acid (17-HDHA), & 14-hydroxydocosahexaenoic acid (14-HDHA)]


Other ingredients: highly refined marine oil concentrate, (squid, anchovy, sardine, herring, mackerel), gelatin, olive oil, glycerin, purified water, lemon flavor, mixed tocopherols.



Dosage and Use
  • Take one (1) softgel daily, with or without food, or as recommended by a healthcare practitioner.
  • Store tightly closed in a cool, dry place.